So, while working on integrating the cfgrid with my demo application, I came accross a conflicts with the CSS that ColdFusion expects to produce for an HTML cfgrid versus the CSS markup from the YUI Base CSS component.
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So, what the Base CSS package does is,
applies a consistent style foundation for common HTML elements
This creates a conflict with the ColdFusion CSS package (which is based on Ext 1.1.1 API). At the same time, you could use this to extend the Base CSS file and define your own styles for the elements. Right now, I just removed Base CSS from my application.